1000 Genomes MCP Server

Example Use Cases

• 1

  Query and analyze genetic variants and genotypes from the 1000 Genomes Project dataset in real-time.

• 2

  Filter variants by genomic annotations, clinical significance, and population metadata.

• 3

  Integrate genomic data access into applications via HTTP or stdio MCP transports.

Description

This MCP server offers real-time querying of over 138 million unique variants and approximately 442 billion individual genotypes from the 1000 Genomes Project dataset. It supports variant, sample, and genotype selection with advanced filtering based on genomic annotations, population data, and pathogenicity scores. The server is implemented in Java EE, accessible via HTTP, HTTP/SSE, and stdio transports, and integrates with the Dnaerys variant store for data retrieval.